We investigated how choline magnesium trisalicylate (CMT) helps alleviate bone pain in patients with metastatic cancer. In a carefully designed study involving 26 participants, we compared CMT against a placebo in a crossover format, measuring pain relief at multiple intervals after dosing.
While we observed a significant reduction in pain just one hour post-treatment with CMT, other comparisons showed improvements that didn't reach statistical significance. This suggested that CMT might assist in managing bone pain, potentially complementing traditional opioids, but overall effectiveness is still under exploration.
Read More
7
Pamidronate therapy reduces bone pain
New trends in the treatment of osteogenesis imperfecta type III - own experience.
We evaluated the effects of pamidronate therapy on children with osteogenesis imperfecta type III. Over the course of treatment, we saw reductions in bone pain, alongside a significant decrease in fracture incidence.
The therapy positively impacted children's daily activities and their overall mobility. Importantly, the treatment was found to be safe, although some patients experienced mild side effects like low calcium levels and a fever. Overall, our findings suggest that bisphosphonate therapy is beneficial for management in these young patients.
Read More
7
Promising drug delivery for osteoporosis
Synthesis and characterization of novel denosumab/magnesium-based metal organic frameworks nanocomposite prepared by ultrasonic route as drug delivery system for the treatment of osteoporosis.
We developed a novel drug delivery system combining denosumab and magnesium within metal-organic frameworks to target osteoarthritis. The framework showed good potential for loaded drug release, delivering about 72% of denosumab in just 8 hours.
Additionally, it released magnesium ions, which are beneficial for bone formation. Our cytotoxicity tests demonstrated that the system is biocompatible and encourages cell growth over time. While our findings are promising for pain relief linked to osteoporosis, further studies are needed to confirm effectiveness in real-world scenarios.
Read More
Most Useful Reviews
9
Back pain relief
5 people found this helpful
The only remedy for my back pain! I suffered from intense back pain and muscle cramps, making it difficult to walk or sleep. The sole solution I found was magnesium citrate. I began taking one tablet daily, and within a week, my pain vanished. I continue taking it before bed and it's transformed my quality of life.
Read More
9
Improves sleep quality
4 people found this helpful
I love Solgar products! The Quality Magnesium Citrate has significantly benefited my mother, improving her bone health and calming her sleep patterns. The tablets are easy to swallow, making this a well-recommended supplement.
Read More
9
Spasm relief
2 people found this helpful
My spasms have ceased. After suffering from excruciating leg pain and cramps, I took magnesium for just five days, and all discomfort has disappeared.
Synthesis and characterization of novel denosumab/magnesium-based metal organic frameworks nanocomposite prepared by ultrasonic route as drug delivery system for the treatment of osteoporosis.
We developed a novel drug delivery system combining denosumab and magnesium within metal-organic frameworks to target osteoarthritis. The framework showed good potential for loaded drug release, delivering about 72% of denosumab in just 8 hours.
Additionally, it released magnesium ions, which are beneficial for bone formation. Our cytotoxicity tests demonstrated that the system is biocompatible and encourages cell growth over time. While our findings are promising for pain relief linked to osteoporosis, further studies are needed to confirm effectiveness in real-world scenarios.
Read More
7
Pamidronate therapy reduces bone pain
New trends in the treatment of osteogenesis imperfecta type III - own experience.
We evaluated the effects of pamidronate therapy on children with osteogenesis imperfecta type III. Over the course of treatment, we saw reductions in bone pain, alongside a significant decrease in fracture incidence.
The therapy positively impacted children's daily activities and their overall mobility. Importantly, the treatment was found to be safe, although some patients experienced mild side effects like low calcium levels and a fever. Overall, our findings suggest that bisphosphonate therapy is beneficial for management in these young patients.
Read More
7
CMT shows potential for pain relief
The efficacy of choline magnesium trisalicylate (CMT) in the management of metastatic bone pain: a pilot study.
We investigated how choline magnesium trisalicylate (CMT) helps alleviate bone pain in patients with metastatic cancer. In a carefully designed study involving 26 participants, we compared CMT against a placebo in a crossover format, measuring pain relief at multiple intervals after dosing.
While we observed a significant reduction in pain just one hour post-treatment with CMT, other comparisons showed improvements that didn't reach statistical significance. This suggested that CMT might assist in managing bone pain, potentially complementing traditional opioids, but overall effectiveness is still under exploration.
Read More
User Reviews
USERS' SCORE
Good
Based on 32 Reviews
8.2
All Reviews
Positive Reviews
Negative Reviews
9
Back pain relief
5 people found this helpful
The only remedy for my back pain! I suffered from intense back pain and muscle cramps, making it difficult to walk or sleep. The sole solution I found was magnesium citrate. I began taking one tablet daily, and within a week, my pain vanished. I continue taking it before bed and it's transformed my quality of life.
Read More
9
Improves sleep quality
4 people found this helpful
I love Solgar products! The Quality Magnesium Citrate has significantly benefited my mother, improving her bone health and calming her sleep patterns. The tablets are easy to swallow, making this a well-recommended supplement.
Read More
9
Spasm relief
2 people found this helpful
My spasms have ceased. After suffering from excruciating leg pain and cramps, I took magnesium for just five days, and all discomfort has disappeared.
Read More
9
Supports bone mineralization
2 people found this helpful
Magnesium promotes healthy bone growth and mineralization, while supporting the nervous and muscular systems. It regulates calcium transport and energy metabolism effectively, ensuring optimal bone health overall.
Read More
10
Supports bone health
1 people found this helpful
I am very satisfied, as this product promotes bone health and supports nerve and muscle function.
Bone pain is a discomfort or ache that originates within the bones themselves and can range from mild to severe. It is different from muscle or joint pain, as it directly affects the skeletal structure. Bone pain can be caused by a variety of factors, including injuries, medical conditions such as osteoarthritis or osteoporosis, infections, or tumors. Symptoms may vary depending on the underlying cause but often include a dull, penetrating ache that may worsen with movement or pressure.
If you're experiencing persistent bone pain, it’s essential to consult with a healthcare professional for a proper diagnosis and treatment plan. Imaging tests like X-rays, MRI, or CT scans may be utilized to determine the root cause of the pain. Treatment can vary widely, ranging from medications to alleviate pain and inflammation to physical therapy or, in some cases, surgical interventions. Understanding the underlying cause is crucial to effectively managing bone pain and ensuring the best path to recovery.
Magnesium is a chemical element with the symbol Mg and atomic number 12. It is a lightweight, silvery-white metal that is a member of the alkaline earth metals group. Often classified as one of the most abundant elements in the Earth's crust, magnesium plays a crucial role in various biological functions and is essential for living organisms. In nature, magnesium can be found in large quantities, primarily in minerals such as dolomite and magnesite, and it is also present in seawater.
In terms of health benefits, magnesium is vital for numerous metabolic processes, including energy production, DNA synthesis, and muscle function. It contributes to bone health, helps regulate blood pressure, and supports bone formation by promoting the effects of vitamin D. The recommended dietary allowance (RDA) for magnesium varies by age and gender, but it is generally important to include magnesium-rich foods like leafy greens, nuts, seeds, and whole grains in your diet to ensure adequate intake. For those who may not receive enough magnesium through their diet alone, supplements are also available; however, it is advisable to consult a healthcare professional before starting any supplementation.
Magnesium plays a crucial role in bone health and may help alleviate some types of bone pain, especially if the pain is related to deficiencies. This essential mineral aids in the regulation of calcium levels in the bone, which is vital for maintaining bone density and overall strength. Some studies have suggested that adequate magnesium intake may reduce the risk of osteoporosis and bone fractures, which are common causes of long-term bone pain. However, if you are experiencing significant or persistent bone pain, it's crucial to consult with a healthcare professional to identify the underlying cause.
While magnesium may provide support for bone health, it should not be viewed as a standalone treatment for bone pain. Incorporating magnesium-rich foods, such as leafy greens, nuts, seeds, and whole grains, can be beneficial in supporting bone health. For some individuals, magnesium supplements may also be considered, but it's important to do this under medical supervision to avoid potential side effects or interactions with other medications. Additionally, a comprehensive approach that includes proper nutrition, exercise, and other lifestyle factors is essential for managing bone health effectively.
Based on user reviews, the timeframe to see results from magnesium citrate supplements for bone pain can vary. Several users reported experiencing significant improvements within a week of starting the supplement. For instance, one reviewer shared that after taking magnesium for just a week, their intense back pain vanished, significantly enhancing their quality of life Read Review. Another user noted that they found relief from leg pain and cramps after just five days Read Review.
However, not all experiences were immediate. A reviewer who has taken the supplement for nearly two months indicated that they observed ongoing improvements, particularly concerning pain fluctuations Read Review. Overall, while some users felt the effects quickly, others suggest that a longer duration might be necessary to achieve optimal results for bone pain relief. It appears that patience and consistent use of the supplement are key to realizing its full benefits.
This supplement shows some promise for alleviating bone pain, particularly through the use of magnesium-based compounds. A study highlighted the potential for magnesium treatment, specifically choline magnesium trisalicylate (CMT), in patients with metastatic cancer. This research found that participants experienced a significant reduction in pain just one hour post-treatment, suggesting that CMT may have a role in managing bone pain, although the overall effectiveness requires further investigation [3].
Additionally, a study developed a novel drug delivery system that combines magnesium with other treatments to target osteoarthritis, indicating that magnesium's properties could be beneficial for bone health and pain relief [1]. Moreover, bisphosphonate therapy has shown to reduce bone pain in children with osteogenesis imperfecta, suggesting that similar mechanisms involving magnesium may have beneficial implications for pain management [2]. While the existing research indicates potential benefits, it's important to approach supplementation with caution and consider the need for further studies to confirm effectiveness in various scenarios.
Based on user reviews, many individuals have reported a range of improvements in symptoms after using magnesium citrate. One of the most frequently mentioned benefits is the alleviation of pain, particularly related to back, leg, and muscle cramps. For instance, one user noted that their intense back pain vanished within a week of starting the supplement, transforming their quality of life entirely Read Review. Another reviewer shared that their leg pain and cramps disappeared after just five days of use Read Review. Such experiences suggest that magnesium citrate can be effective for those struggling with muscle spasms and discomfort.
Additionally, users have highlighted improvements in sleep quality and overall health. Some have found that magnesium significantly enhances their ability to relax and fall asleep pain-free, as evidenced by a reviewer who experienced an 80% reduction in post-exercise muscle pain, allowing for deeper sleep after starting the product Read Review. It is important to note that while many have witnessed quick benefits, others have reported ongoing improvements over several weeks, with one user experiencing a reduction in migraine frequency after two months Read Review. Overall, individual results can vary, but many users find magnesium citrate to be a valuable aid for pain relief and enhanced well-being.
Based on user reviews, many individuals reported positive experiences when combining magnesium citrate with other supplements for handling bone pain. Users mentioned that magnesium promotes healthy bone growth and mineralization, effectively supporting the nervous and muscular systems, and regulating calcium transport. One reviewer highlighted that magnesium helped alleviate their bone pain significantly, which they attributed to this enhanced calcium absorption and overall improvement in bone health Read Review. Additionally, another reviewer noted how this product improved their overall health, including enhanced sleep quality, thereby indirectly benefiting their experience with bone pain Read Review.
Moreover, some users found success in layering magnesium citrate with other supplements to maximize their benefits for bone pain relief. For example, while one user reported significant improvements in sleep and pain alleviation, this was also accompanied by advice from a doctor to take multiple tablets daily with meals, indicating a tailored approach to supplementation for severe joint and muscle pain Read Review. Overall, combining magnesium citrate with other complementary supplements seems to have aided many users in their struggle with bone pain, showcasing its versatility in enhancing overall health and pain relief.
The optimal dose for magnesium treatment in alleviating bone pain remains to be clarified, as current research indicates varying effects and dosages. A study involving choline magnesium trisalicylate (CMT) found significant pain relief in the first hour post-treatment, suggesting it could be beneficial for those experiencing bone pain related to conditions like metastatic cancer [3]. However, the study did not define a specific dose that achieved consistent results across all participants, indicating a need for more targeted research in this area.
Further, findings from other studies suggest magnesium's promising role in supporting bone health, particularly in osteoporosis, but they also highlight the necessity for more conclusive data regarding optimal dosing to ensure both safety and efficacy [1]. According to the available research, while magnesium shows potential as a complementary treatment for pain management, specific dosing guidelines have yet to be firmly established. Those considering magnesium for bone pain should consult with a healthcare professional to determine an appropriate regimen tailored to their individual needs.
9
Back pain relief
5 people found this helpful
The only remedy for my back pain! I suffered from intense back pain and muscle cramps, making it difficult to walk or sleep. The sole solution I found was magnesium citrate. I began taking one tablet daily, and within a week, my pain vanished. I continue taking it before bed and it's transformed my quality of life.
9
Spasm relief
2 people found this helpful
My spasms have ceased. After suffering from excruciating leg pain and cramps, I took magnesium for just five days, and all discomfort has disappeared.
7.5
Migraine relief
20 people found this helpful
Excellent! I was searching for a way to combat migraines. I started taking magnesium, as my migraine attacks had increased to twice a month, accompanied by leg cramps during episodes. It's terrible; I wouldn't wish that on anyone. I had begun using it and found it beneficial. After nearly two months, I can say it has helped! Now, I have migraines only once a month, and the pain is tolerable without the need for medication. I hope to rid myself of this trouble for good.
8
Muscle pain reduction
1 people found this helpful
This is a wonderful product! I had muscle pain after exercising and found it difficult to fall asleep. After using this product, my pain has reduced by 80%. Now when I sleep, I do so very deeply. Highly recommend!
7.5
Reduces pain overall
4 people found this helpful
I’m very satisfied with this magnesium, which I’ve taken for years. It greatly reduces my bone pain, although I wish Solgar would remove Titanium Dioxide from their supplements, as it’s harmful.
7.5
Beneficial for elderly
1 people found this helpful
This Magnesium Citrate is beneficial for bones and joints. I purchased it for my elderly aunt, and she felt improvements in her overall health and sleep quality. The product was well-packaged and delivered promptly.
7.5
Improved sleep quality
3 people found this helpful
This quality dietary supplement is excellent regarding bioavailability. Following my doctor’s advice, I took three tablets daily with meals to mitigate stress and restore magnesium levels. I suffered from joint and muscle pain, resulting in restless sleep. Magnesium citrate significantly helped with night cramps, and I felt better health almost immediately. The large tablets are easy to swallow, with a neutral taste.
7
CMT shows potential for pain relief
The efficacy of choline magnesium trisalicylate (CMT) in the management of metastatic bone pain: a pilot study.
We investigated how choline magnesium trisalicylate (CMT) helps alleviate bone pain in patients with metastatic cancer. In a carefully designed study involving 26 participants, we compared CMT against a placebo in a crossover format, measuring pain relief at multiple intervals after dosing.
While we observed a significant reduction in pain just one hour post-treatment with CMT, other comparisons showed improvements that didn't reach statistical significance. This suggested that CMT might assist in managing bone pain, potentially complementing traditional opioids, but overall effectiveness is still under exploration.
7
Promising drug delivery for osteoporosis
Synthesis and characterization of novel denosumab/magnesium-based metal organic frameworks nanocomposite prepared by ultrasonic route as drug delivery system for the treatment of osteoporosis.
We developed a novel drug delivery system combining denosumab and magnesium within metal-organic frameworks to target osteoarthritis. The framework showed good potential for loaded drug release, delivering about 72% of denosumab in just 8 hours.
Additionally, it released magnesium ions, which are beneficial for bone formation. Our cytotoxicity tests demonstrated that the system is biocompatible and encourages cell growth over time. While our findings are promising for pain relief linked to osteoporosis, further studies are needed to confirm effectiveness in real-world scenarios.
7
Pamidronate therapy reduces bone pain
New trends in the treatment of osteogenesis imperfecta type III - own experience.
We evaluated the effects of pamidronate therapy on children with osteogenesis imperfecta type III. Over the course of treatment, we saw reductions in bone pain, alongside a significant decrease in fracture incidence.
The therapy positively impacted children's daily activities and their overall mobility. Importantly, the treatment was found to be safe, although some patients experienced mild side effects like low calcium levels and a fever. Overall, our findings suggest that bisphosphonate therapy is beneficial for management in these young patients.
References
Alsaikhan F, Mahmoud MZ, Suliman M. Synthesis and characterization of novel denosumab/magnesium-based metal organic frameworks nanocomposite prepared by ultrasonic route as drug delivery system for the treatment of osteoporosis. Front Bioeng Biotechnol. 2023;11:1153969. doi:10.3389/fbioe.2023.1153969
Jakubowska-Pietkiewicz E, Chlebna-Sokół D. New trends in the treatment of osteogenesis imperfecta type III - own experience. Ortop Traumatol Rehabil. 2008;10:593.
Johnson JR, Miller AJ. The efficacy of choline magnesium trisalicylate (CMT) in the management of metastatic bone pain: a pilot study. Palliat Med. 1994;8:129.